Editorial: Protein‐protein interactions: Mimics and inhibitors

Rational Design of Topographical Helix Mimics as Potent Inhibitors of Protein–Protein Interactions

Protein-protein interactions encompass large surface areas, but often a handful of key residues dominate the binding energy landscape. Rationally designed small molecule scaffolds that reproduce the relative positioning and disposition of important binding residues, termed "hotspot residues", have been shown to successfully inhibit specific protein complexes. Although this strategy has led to d...

Mining Gene-Disease Relationships from Biomedical Literature: Weighting Proteinprotein Interactions and Connectivity

Motivation: The promises of the post-genome era disease-related discoveries and advances have yet to be fully realized, with many opportunities for discovery hiding in the millions of biomedical papers published since. Public databases give access to data extracted from the literature by teams of experts, but their coverage is often limited and lags behind recent discoveries. We present a compu...

HIV gp41 trimer mimics for vaccines and fusion inhibitors

Using DharmaconTM Mimics and Inhibitors for microRNA Functional Analysis

Introduction: microRNAs (miRNAs) are naturally occurring short RNA molecules of about 22 nucleotide (nt) long that regulate gene expression by binding to target mRNA and suppressing its translation or initiating its degradation.1 Since their initial description in C. elegans in 1993, almost four thousand miRNAs in over 40 species of animals, plants and viruses have been identified.2 Subsequent ...

Editorial: Biotrophic Plant-Microbe Interactions

Organisms inhabit the biosphere not as isolated entities: they interact with others. These may be individuals of the same species. In fact, the most common interactions are likely to be with very different beings. The interactions may be fleeting, or life-long, they may be simply sharing the same space, or may be complex behavioral and developmental processes (Buxa et al.; Genre and Russo) from...